Atherogenesis, atherosclerosis and related diseases: unresolved issues

Addressing the Unresolved Issues

The landscape of early breast cancer has changed dramatically with significant advancements in early screening and diagnosis and curative-intent therapies. Indeed, breast cancer–specific survival has improved by 20% during the past 30 years, and 5-year survival is now 98% for early-stage disease.1 As a consequence, the risk and nature of adjuvant therapy–induced immediate and late-occurring car...

Unresolved intergenerational issues.

Venous thromboembolism diagnosis: unresolved issues.

Recent advances in the management of patients with suspected VTE have both improved diagnostic accuracy and made management algorithms safer, easier to use and well standardised. These diagnostic algorithms are mainly based on the assessment of clinical pretest probability, D-dimer measurement and imaging tests, mainly represented by compression ultrasound (CUS) for suspected DVT and computed t...

Unresolved Issues in Ontology Learning

Despite a number of approaches to ontology learning in the last decade, there are still a number of challenges that need to be tackled by the research community. This paper describes some of these challenges and sketches some ideas that might be beneficial for solving them.

Rethinking primary prevention of atherosclerosis-related diseases.

Crucial advances in our understanding of basic pathogenic mechanisms involved in atherogenesis have been achieved during the past 2 decades. The historical hypothesis of pathogenesis (“lipid accumulation”) has evolved to integrate several causal events contributing to the initiation and evolution of atherosclerosis. Vascular inflammation and apoptosis may play a joint pivotal role in its progre...